Face masks for the...Face masks for the public during the covid-19 crisis;, , , , 1Nuffield Department of Primary Care Health Sciences, University of Oxford2Neonatal Department, University Hospital of Zurich, Switzerland3University of Zurich, Zurich, Switzerland4Institute for Advanced Studies, Vienna, Austria5London School of Economics, London, UK6University of Edinburgh, UK7University of Glasgow, UKCorrespondence to: T Greenhalgh Trisha Greenhalgh and colleagues argue that it is time to apply the precautionary principleThe precautionary principle is, according to Wikipedia, “a strategy for...…Face masks for the...Face masks for the public during the covid-19 crisis;, , , , 1Nuffield Department of Primary Care Health Sciences, University of Oxford2Neonatal Department, University Hospital of Zurich, Switzerland3University of Zurich, Zurich, Switzerland4Institute for Advanced Studies, Vienna, Austria5London School of Economics, London, UK6University of Edinburgh, UK7University of Glasgow, UKCorrespondence to: T Greenhalgh Trisha Greenhalgh and colleagues argue that it is time to apply the precautionary principleThe precautionary principle is, according to Wikipedia, “a strategy for...WW…

Edited by Florencia Torche, Stanford University, Stanford, CA, and approved February 26, 2021 (received for review October 26, 2020)School closures have been a common tool in the battle against COVID-19. Yet, their costs and benefits remain insufficiently known. We use a natural experiment that occurred as national examinations in The Netherlands took place before and after lockdown to evaluate the impact of school closures on students’ learning. The Netherlands is interesting as a “best-case” scenario, with a short lockdown, equitable school funding, and world-leading rates of broadband...…Edited by Florencia Torche, Stanford University, Stanford, CA, and approved February 26, 2021 (received for review October 26, 2020)School closures have been a common tool in the battle against COVID-19. Yet, their costs and benefits remain insufficiently known. We use a natural experiment that occurred as national examinations in The Netherlands took place before and after lockdown to evaluate the impact of school closures on students’ learning. The Netherlands is interesting as a “best-case” scenario, with a short lockdown, equitable school funding, and world-leading rates of broadband...WW…

Blood vessels provide supportive microenvironments for maintaining tissue functions. Age-associated vascular changes and their relation to tissue aging and pathology are poorly understood. Here, we perform 3D imaging of young and aging vascular beds. Multiple organs in mice and humans demonstrate an age-dependent decline in vessel density and pericyte numbers, while highly remodeling tissues such as skin preserve the vasculature. Vascular attrition precedes the appearance of cellular hallmarks of aging such as senescence. Endothelial VEGFR2 loss-of-function mice demonstrate that vascular...…Blood vessels provide supportive microenvironments for maintaining tissue functions. Age-associated vascular changes and their relation to tissue aging and pathology are poorly understood. Here, we perform 3D imaging of young and aging vascular beds. Multiple organs in mice and humans demonstrate an age-dependent decline in vessel density and pericyte numbers, while highly remodeling tissues such as skin preserve the vasculature. Vascular attrition precedes the appearance of cellular hallmarks of aging such as senescence. Endothelial VEGFR2 loss-of-function mice demonstrate that vascular...WW…

Article TextOriginal researchEstimating the burden of the COVID-19 pandemic on mortality, life expectancy and lifespan inequality in England and Wales: a population-level analysisBackground Deaths directly linked to COVID-19 infection may be misclassified, and the pandemic may have indirectly affected other causes of death. To overcome these measurement challenges, we estimate the impact of the COVID-19 pandemic on mortality, life expectancy and lifespan inequality from week 10 of 2020, when the first COVID-19 death was registered, to week 47 ending 20 November 2020 in England and Wales...…Article TextOriginal researchEstimating the burden of the COVID-19 pandemic on mortality, life expectancy and lifespan inequality in England and Wales: a population-level analysisBackground Deaths directly linked to COVID-19 infection may be misclassified, and the pandemic may have indirectly affected other causes of death. To overcome these measurement challenges, we estimate the impact of the COVID-19 pandemic on mortality, life expectancy and lifespan inequality from week 10 of 2020, when the first COVID-19 death was registered, to week 47 ending 20 November 2020 in England and Wales...WW…

You are currently viewing the abstract.AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.Log in via OpenAthens.Log in with your institution via Shibboleth.Download and print this article for your personal scholarly, research, and educational use.Buy a single issue of Science for just $15 USD.To have any hope of meeting the central goal of the Paris Agreement, which is to limit global warming to 2°C or less, our carbon emissions must be reduced considerably, including those coming...…You are currently viewing the abstract.AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.Log in via OpenAthens.Log in with your institution via Shibboleth.Download and print this article for your personal scholarly, research, and educational use.Buy a single issue of Science for just $15 USD.To have any hope of meeting the central goal of the Paris Agreement, which is to limit global warming to 2°C or less, our carbon emissions must be reduced considerably, including those coming...WW…