Share this articleDoiCopy to clipboardCite this articleThe yeast mating-type switching endonuclease HO is a domesticated member of an unorthodox homing genetic element familyeLife 9:e55336.Copy to clipboardThe mating-type switching endonuclease HO plays a central role in the natural life cycle of Saccharomyces cerevisiae, but its evolutionary origin is unknown. HO is a recent addition to yeast genomes, present in only a few genera close to Saccharomyces. Here we show that HO is structurally and phylogenetically related to a family of unorthodox homing genetic elements found in Torulaspora...…Share this articleDoiCopy to clipboardCite this articleThe yeast mating-type switching endonuclease HO is a domesticated member of an unorthodox homing genetic element familyeLife 9:e55336.Copy to clipboardThe mating-type switching endonuclease HO plays a central role in the natural life cycle of Saccharomyces cerevisiae, but its evolutionary origin is unknown. HO is a recent addition to yeast genomes, present in only a few genera close to Saccharomyces. Here we show that HO is structurally and phylogenetically related to a family of unorthodox homing genetic elements found in Torulaspora...WW…

Phys. Rev. Research 2, 033499 – Published 25 September 2020 We introduce interpretable siamese neural networks (SNNs) for similarity detection to the field of theoretical physics. More precisely, we apply SNNs to events in special relativity, the transformation of electromagnetic fields, and the motion of particles in a central potential. In these examples, SNNs learn to identify data points belonging to the same event, field configuration, or trajectory of motion. We demonstrate that in the process of learning which data points belong to the same event or field configuration, these SNNs...…Phys. Rev. Research 2, 033499 – Published 25 September 2020 We introduce interpretable siamese neural networks (SNNs) for similarity detection to the field of theoretical physics. More precisely, we apply SNNs to events in special relativity, the transformation of electromagnetic fields, and the motion of particles in a central potential. In these examples, SNNs learn to identify data points belonging to the same event, field configuration, or trajectory of motion. We demonstrate that in the process of learning which data points belong to the same event or field configuration, these SNNs...WW…

Edited by Arild Underdal, University of Oslo, Oslo, Norway, and approved March 2, 2020 (received for review October 16, 2019)International carbon markets are an appealing and increasingly popular tool to regulate carbon emissions. They put a price on carbon emissions and make pollution less attractive for regulated firms. However, carbon markets often produce prices which are deemed too low relative to the social cost of carbon. We argue that despite low prices, carbon markets can help reduce emissions. Using a statistical model and sectoral emissions data, we find that the EU ETS, which...…Edited by Arild Underdal, University of Oslo, Oslo, Norway, and approved March 2, 2020 (received for review October 16, 2019)International carbon markets are an appealing and increasingly popular tool to regulate carbon emissions. They put a price on carbon emissions and make pollution less attractive for regulated firms. However, carbon markets often produce prices which are deemed too low relative to the social cost of carbon. We argue that despite low prices, carbon markets can help reduce emissions. Using a statistical model and sectoral emissions data, we find that the EU ETS, which...WW…

Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections. However, only a small percentage of high-risk (HR) HPV infections progress to cervical precancer and cancer. In this study, we investigated the role of the cervicovaginal microbiome (CVM) in the natural history of HR-HPV.This study was nested within the placebo arm of the Costa Rica HPV Vaccine Trial that included women aged 18–25 years of age. Cervical samples from two visits of women with an incident HR-HPV infection (n = 273 women) were used to evaluate the prospective role of the CVM on the...…Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections. However, only a small percentage of high-risk (HR) HPV infections progress to cervical precancer and cancer. In this study, we investigated the role of the cervicovaginal microbiome (CVM) in the natural history of HR-HPV.This study was nested within the placebo arm of the Costa Rica HPV Vaccine Trial that included women aged 18–25 years of age. Cervical samples from two visits of women with an incident HR-HPV infection (n = 273 women) were used to evaluate the prospective role of the CVM on the...WW…

Next Article in JournalPrevious Article in JournalPrevious Article in Special IssueYou are accessing a machine-readable page. In order to be human-readable, please install an RSS reader.All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited.Feature...…Next Article in JournalPrevious Article in JournalPrevious Article in Special IssueYou are accessing a machine-readable page. In order to be human-readable, please install an RSS reader.All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited.Feature...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.Advertisement‘Dysbiosis’ of the maternal gut microbiome, in response to challenges such as infection, altered diet and stress during pregnancy, has been increasingly associated with abnormalities in brain function and behaviour of the offspring. However, it is...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.Advertisement‘Dysbiosis’ of the maternal gut microbiome, in response to challenges such as infection, altered diet and stress during pregnancy, has been increasingly associated with abnormalities in brain function and behaviour of the offspring. However, it is...WW…

Javascript is disabled in your browser. Please to view PeerJ.DownloadSharePEER-REVIEWEDView articleData reuse is an essential component of open science and has been facilitated by the ‘big data’ revolution. The transition from (hand) written notes to datasets stored on hard drives can be viewed as the first step on the road to effective data reuse in the life sciences (), allowing the generation of multiple copies at almost no additional cost. The second step was improved connectivity, which was enabled by the internet. Together, these technological advances in data storage and transfer...…Javascript is disabled in your browser. Please to view PeerJ.DownloadSharePEER-REVIEWEDView articleData reuse is an essential component of open science and has been facilitated by the ‘big data’ revolution. The transition from (hand) written notes to datasets stored on hard drives can be viewed as the first step on the road to effective data reuse in the life sciences (), allowing the generation of multiple copies at almost no additional cost. The second step was improved connectivity, which was enabled by the internet. Together, these technological advances in data storage and transfer...WW…