Share this articleDoiCopy to clipboardCite this articleThe yeast mating-type switching endonuclease HO is a domesticated member of an unorthodox homing genetic element familyeLife 9:e55336.Copy to clipboardThe mating-type switching endonuclease HO plays a central role in the natural life cycle of Saccharomyces cerevisiae, but its evolutionary origin is unknown. HO is a recent addition to yeast genomes, present in only a few genera close to Saccharomyces. Here we show that HO is structurally and phylogenetically related to a family of unorthodox homing genetic elements found in Torulaspora...…Share this articleDoiCopy to clipboardCite this articleThe yeast mating-type switching endonuclease HO is a domesticated member of an unorthodox homing genetic element familyeLife 9:e55336.Copy to clipboardThe mating-type switching endonuclease HO plays a central role in the natural life cycle of Saccharomyces cerevisiae, but its evolutionary origin is unknown. HO is a recent addition to yeast genomes, present in only a few genera close to Saccharomyces. Here we show that HO is structurally and phylogenetically related to a family of unorthodox homing genetic elements found in Torulaspora...WW…