Edited by William A. Eaton, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, and approved February 17, 2021 (received for review September 13, 2020)The tendency of many cellular proteins to form protein-rich biomolecular condensates underlies the formation of subcellular compartments and has been linked to various physiological functions. Understanding the molecular basis of this fundamental process and predicting protein phase behavior have therefore become important objectives. To develop a global understanding of how protein sequence determines its phase...…Edited by William A. Eaton, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, and approved February 17, 2021 (received for review September 13, 2020)The tendency of many cellular proteins to form protein-rich biomolecular condensates underlies the formation of subcellular compartments and has been linked to various physiological functions. Understanding the molecular basis of this fundamental process and predicting protein phase behavior have therefore become important objectives. To develop a global understanding of how protein sequence determines its phase...WW…

Edited by Lucio Frydman, Weizmann Institute of Science, Rehovot, Israel, and accepted by Editorial Board Member Angela M. Gronenborn February 16, 2021 (received for review July 11, 2020)There is an unmet clinical need for sensitive methods for detecting cell death in vivo, for example, in disease and following tumor treatment. We show here that deuterium magnetic resonance measurements at 7 T of labeled malate production from injected 2H-labeled fumarate provide a sensitive method for detecting tumor cell death in vivo following treatment. Malate production was relatively slow in viable...…Edited by Lucio Frydman, Weizmann Institute of Science, Rehovot, Israel, and accepted by Editorial Board Member Angela M. Gronenborn February 16, 2021 (received for review July 11, 2020)There is an unmet clinical need for sensitive methods for detecting cell death in vivo, for example, in disease and following tumor treatment. We show here that deuterium magnetic resonance measurements at 7 T of labeled malate production from injected 2H-labeled fumarate provide a sensitive method for detecting tumor cell death in vivo following treatment. Malate production was relatively slow in viable...WW…

Article TextOriginal researchLongitudinal increases in childhood depression symptoms during the COVID-19 lockdownObjective There has been widespread concern that so-called lockdown measures, including social distancing and school closures, could negatively impact children’s mental health. However, there has been little direct evidence of any association due to the paucity of longitudinal studies reporting mental health before and during the lockdown. This present study provides the first longitudinal examination of changes in childhood mental health, a key component of an urgently needed...…Article TextOriginal researchLongitudinal increases in childhood depression symptoms during the COVID-19 lockdownObjective There has been widespread concern that so-called lockdown measures, including social distancing and school closures, could negatively impact children’s mental health. However, there has been little direct evidence of any association due to the paucity of longitudinal studies reporting mental health before and during the lockdown. This present study provides the first longitudinal examination of changes in childhood mental health, a key component of an urgently needed...WW…