Sharon Begley
Sharon Begley
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Experts envision two scenarios if the new coronavirus isn't contained

Experts envision two scenarios if the new coronavirus isn't contained

ith the spreading from person to person (possibly including from people without symptoms), reaching four continents, and traveling faster than SARS, driving it out of existence is looking increasingly unlikely.It’s still possible that quarantines and travel bans will first halt the outbreak and then eradicate the microbe, and the world will never see again, as epidemiologist Dr. Mike Ryan, head of health emergencies at the World Health Organization, STAT on Saturday. That’s what happened with SARS in 2003.Many experts, however, view that happy outcome as increasingly unlikely. “Independent...

March 10, 2020
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Brainiacs, not birdbrains: Crows possess higher intelligence long thought a primarily human attribute

Brainiacs, not birdbrains: Crows possess higher intelligence long thought a primarily human attribute

hether crows, ravens, and other “corvids” are making multipart tools like hooked sticks to reach grubs, solving geometry puzzles made famous by Aesop, or nudging a clueless hedgehog before it becomes roadkill, they have long impressed scientists with their intelligence and creativity.Now the birds can add one more feather to their brainiac claims: unveiled on Thursday in Science finds that crows know what they know and can ponder the content of their own minds, a manifestation of higher intelligence and analytical thought long believed the sole province of humans and a few other higher...

September 24, 2020
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Gene-editing discovery could point the way toward a 'holy grail': cures for mitochondrial diseases

Gene-editing discovery could point the way toward a 'holy grail': cures for mitochondrial diseases

iologist David Liu was in the middle of his morning commute to the Broad Institute two summers ago when he opened the email. We just discovered a new toxin made by bacteria, explained the note from a researcher Liu had never spoken to, and it “might be useful for something you guys do.”Intrigued, Liu phoned the sender, biologist Joseph Mougous of the University of Washington, and it quickly became clear that the bacterial toxin had a talent that was indeed useful for what Liu does: invent ways to edit genes. On Wednesday, they and their colleagues reported in Nature that they had turned the...

July 8, 2020
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A secret experiment revealed: In a medical first, doctors treat Parkinson’s with a novel brain cell transplant

A secret experiment revealed: In a medical first, doctors treat Parkinson’s with a novel brain cell transplant

First of two parts.month before the scheduled surgery, the four researchers were ready to chaperone the brain cells on their 190-mile journey. They never anticipated they were in for “The Amazing Race”-meets-“ER.”It was after midnight on a late summer night in 2017, and they had less than eight hours to get the cells by ambulance, private plane, and another ambulance from Dana-Farber Cancer Institute in Boston to Weill Cornell Medical Center in Manhattan. If it took longer, the cells would almost certainly be DOA, and so might the researchers’ plan to carry out an experimental transplant...

May 12, 2020
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Many states are far short of Covid-19 testing levels needed for safe reopening, new analysis shows

Many states are far short of Covid-19 testing levels needed for safe reopening, new analysis shows

ore than half of U.S. states will have to significantly step up their Covid-19 testing to even consider starting to relax stay-at-home orders after May 1, according to a new analysis by Harvard researchers and STAT.The analysis shows that as the U.S. tries to move beyond its months-long coronavirus testing debacle — faulty tests, shortages of tests, and guidelines that excluded many people who should have been tested to mitigate the outbreak — it is at risk of fumbling the next challenge: testing enough people to determine which cities and states can safely reopen and stay open. Doing so...

April 27, 2020
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Influential Covid-19 model uses flawed methods and shouldn't guide U.S. policies, critics say

Influential Covid-19 model uses flawed methods and shouldn't guide U.S. policies, critics say

widely followed model for projecting Covid-19 deaths in the U.S. is producing results that have been bouncing up and down like an unpredictable fever, and now epidemiologists are criticizing it as flawed and misleading for both the public and policy makers. In particular, they warn against relying on it as the basis for government decision-making, including on “re-opening America.”“It’s not a model that most of us in the infectious disease epidemiology field think is well suited” to projecting Covid-19 deaths, epidemiologist Marc Lipsitch of the Harvard T.H. Chan School of Public Health...

April 17, 2020
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New analysis breaks down age-group risk for coronavirus — and shows millennials are not invincible

New analysis breaks down age-group risk for coronavirus — and shows millennials are not invincible

s the Covid-19 pandemic takes an ever-larger toll across the world, researchers are expanding their understanding of who is at greatest risk of infection, serious illness, and death, detailed information that earlier had been reported only by China, where the outbreak began late last year.In general, the U.S. experience largely mimics China’s, with the risk for serious disease and death from Covid-19 rising with age. But in an important qualification, an reported on Wednesday underlines a message that infectious disease experts have been emphasizing: Millennials . The new data show that up...

March 18, 2020
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Who is getting sick, and how sick? A breakdown of coronavirus risk by demographic factors

Who is getting sick, and how sick? A breakdown of coronavirus risk by demographic factors

he new is not an equal-opportunity killer: Being elderly and having other illnesses, for instance, greatly increases the risk of dying from the disease the virus causes, Covid-19. It’s also possible being male could put you at increased risk.For both medical and public health reasons, researchers want to figure out who’s most at risk of being infected and who’s most at risk of developing severe or even lethal illness. With that kind of information, clinicians would know whom to treat more aggressively, government officials would have a better idea of steps to take, and everyone would know...

March 10, 2020
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Racial bias skews algorithms widely used to guide care from heart surgery to birth, study finds

Racial bias skews algorithms widely used to guide care from heart surgery to birth, study finds

ecision aids that U.S. physicians use to guide patient care on everything from who receives heart surgery to who needs kidney care and who should try to give birth vaginally are racially biased, scientists on Wednesday in the New England Journal of Medicine.It is the latest evidence that algorithms used by hospitals and physicians to guide the health care given to tens of millions of Americans are shot through with implicit racism that their creators are often unaware of, but which nevertheless often result in Black people receiving inferior care.The new findings cut across more medical...

June 17, 2020
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Records Found in Dusty Basement Undermine Decades of Dietary Advice

Records Found in Dusty Basement Undermine Decades of Dietary Advice

If biology has an Indiana Jones, it is Christopher Ramsden: he specializes in excavating lost studies, particularly those with the potential to challenge mainstream, government-sanctioned health advice.His latest excavation—made possible by the pack-rat habits of a deceased scientist, the help of the scientist’s sons, and computer technicians who turned punch cards and magnetic tape into formats readable by today’s computers—undercuts a pillar of nutrition science.Ramsden, of the National Institutes of Health, unearthed raw data from a 40-year-old study, which challenges...

June 1, 2020
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