You are currently viewing the abstract.AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.Log in via OpenAthens.Log in with your institution via Shibboleth.Download and print this article for your personal scholarly, research, and educational use.Buy a single issue of Science for just $15 USD.Immune checkpoint blockade and other immunotherapies for cancer have shown promising results but are still limited in their effectiveness. Adding natural killer cells to immunotherapy regimens...…You are currently viewing the abstract.AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.Log in via OpenAthens.Log in with your institution via Shibboleth.Download and print this article for your personal scholarly, research, and educational use.Buy a single issue of Science for just $15 USD.Immune checkpoint blockade and other immunotherapies for cancer have shown promising results but are still limited in their effectiveness. Adding natural killer cells to immunotherapy regimens...WW…

Article TextEpidemiology/Health services researchAdditive effects of green tea and coffee on all-cause mortality in patients with type 2 diabetes mellitus: the Fukuoka Diabetes RegistryIntroduction The impact of consuming green tea or coffee on mortality in patients with diabetes is controversial. We prospectively investigated the impact of each beverage and their combination on mortality among Japanese patients with type 2 diabetes.Research design and methods In all, 4923 patients (2790 men, 2133 women) with type 2 diabetes (mean age, 66 years) were followed prospectively (median, 5.3...…Article TextEpidemiology/Health services researchAdditive effects of green tea and coffee on all-cause mortality in patients with type 2 diabetes mellitus: the Fukuoka Diabetes RegistryIntroduction The impact of consuming green tea or coffee on mortality in patients with diabetes is controversial. We prospectively investigated the impact of each beverage and their combination on mortality among Japanese patients with type 2 diabetes.Research design and methods In all, 4923 patients (2790 men, 2133 women) with type 2 diabetes (mean age, 66 years) were followed prospectively (median, 5.3...WW…

COVID-19 has become a global pandemic caused by the novel coronavirus SARS-CoV-2.Understanding the origins of SARS-CoV-2 is critical for deterring futurezoonosis, discovering new drugs, and developing a vaccine. We show evidence ofstrong purifying selection around the receptor binding motif (RBM) in the spikeand other genes among bat, pangolin, and human coronaviruses, suggesting similarevolutionary constraints in different host species. We also demonstrate thatSARS-CoV-2’s entire RBM was introduced through recombination withcoronaviruses from pangolins, possibly a critical step in the...…COVID-19 has become a global pandemic caused by the novel coronavirus SARS-CoV-2.Understanding the origins of SARS-CoV-2 is critical for deterring futurezoonosis, discovering new drugs, and developing a vaccine. We show evidence ofstrong purifying selection around the receptor binding motif (RBM) in the spikeand other genes among bat, pangolin, and human coronaviruses, suggesting similarevolutionary constraints in different host species. We also demonstrate thatSARS-CoV-2’s entire RBM was introduced through recombination withcoronaviruses from pangolins, possibly a critical step in the...WW…