Between early March and 1 August 2020, COVID-19 took the lives of more than 150,000 Americans. Here, we examine the political consequences of the COVID-19 epidemic using granular data on COVID-19 fatalities and the attitudes of the American public. We find that COVID-19 has led to substantial damage for President Trump and other Republican candidates. States and local areas with higher levels of COVID-19 fatalities are less likely to support President Trump and Republican candidates for House and Senate. Our results show that President Trump and other Republican candidates would benefit...…Between early March and 1 August 2020, COVID-19 took the lives of more than 150,000 Americans. Here, we examine the political consequences of the COVID-19 epidemic using granular data on COVID-19 fatalities and the attitudes of the American public. We find that COVID-19 has led to substantial damage for President Trump and other Republican candidates. States and local areas with higher levels of COVID-19 fatalities are less likely to support President Trump and Republican candidates for House and Senate. Our results show that President Trump and other Republican candidates would benefit...WW…