Edited by Douglas S. Massey, Princeton University, Princeton, NJ, and approved January 21, 2021 (received for review October 16, 2020)Acceptance of vaccines has been on the decline in recent years. Despite encouraging early results for coronavirus vaccine trials, achieving herd immunity requires substantial uptake. We presented scenarios varying vaccine efficacy, minor side effects, and severe reactions to a sample representative of the US population. Vaccine acceptance improved when the efficacy increased beyond 70%. Respondents were unaffected by the probability of minor side effects,...…Edited by Douglas S. Massey, Princeton University, Princeton, NJ, and approved January 21, 2021 (received for review October 16, 2020)Acceptance of vaccines has been on the decline in recent years. Despite encouraging early results for coronavirus vaccine trials, achieving herd immunity requires substantial uptake. We presented scenarios varying vaccine efficacy, minor side effects, and severe reactions to a sample representative of the US population. Vaccine acceptance improved when the efficacy increased beyond 70%. Respondents were unaffected by the probability of minor side effects,...WW…