Contributed by Joan A. Steitz, February 22, 2021 (sent for review December 29, 2020; reviewed by Elena Conti, Karin Musier-Forsyth, and Hongwei Wang)RNA triple helices were characterized in vitro over 60 y ago, but only recently implicated in diverse biological activities. The element for nuclear expression (ENE) protects RNA from degradation via triplex formation with the poly(A) tail on the 3ʹ ends of cellular RNAs. ENEs appear in diverse genomes, including a category containing two ENEs separated by a double-stranded region (dENEs). Using structure probing, SAXS, and cryo-EM, we show...…Contributed by Joan A. Steitz, February 22, 2021 (sent for review December 29, 2020; reviewed by Elena Conti, Karin Musier-Forsyth, and Hongwei Wang)RNA triple helices were characterized in vitro over 60 y ago, but only recently implicated in diverse biological activities. The element for nuclear expression (ENE) protects RNA from degradation via triplex formation with the poly(A) tail on the 3ʹ ends of cellular RNAs. ENEs appear in diverse genomes, including a category containing two ENEs separated by a double-stranded region (dENEs). Using structure probing, SAXS, and cryo-EM, we show...WW…

You are currently viewing the abstract.AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.Log in via OpenAthens.Log in with your institution via Shibboleth.Download and print this article for your personal scholarly, research, and educational use.Buy a single issue of Science for just $15 USD.The RNA World Hypothesis suggests that, before modern life, there were RNA molecules that were capable of carrying genetic information and driving chemical reactions, a task gradually replaced...…You are currently viewing the abstract.AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.Log in via OpenAthens.Log in with your institution via Shibboleth.Download and print this article for your personal scholarly, research, and educational use.Buy a single issue of Science for just $15 USD.The RNA World Hypothesis suggests that, before modern life, there were RNA molecules that were capable of carrying genetic information and driving chemical reactions, a task gradually replaced...WW…

You are currently viewing the abstract.AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.Log in via OpenAthens.Log in with your institution via Shibboleth.Download and print this article for your personal scholarly, research, and educational use.Buy a single issue of Science for just $15 USD.One of the most conserved RNA modifications across organisms is the addition of a polyadenosine, or poly(A), tail to the 3′ end of RNA molecules. Cis-acting RNA stabilization elements, such as...…You are currently viewing the abstract.AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.Log in via OpenAthens.Log in with your institution via Shibboleth.Download and print this article for your personal scholarly, research, and educational use.Buy a single issue of Science for just $15 USD.One of the most conserved RNA modifications across organisms is the addition of a polyadenosine, or poly(A), tail to the 3′ end of RNA molecules. Cis-acting RNA stabilization elements, such as...WW…