Edited by William A. Eaton, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, and approved February 17, 2021 (received for review September 13, 2020)The tendency of many cellular proteins to form protein-rich biomolecular condensates underlies the formation of subcellular compartments and has been linked to various physiological functions. Understanding the molecular basis of this fundamental process and predicting protein phase behavior have therefore become important objectives. To develop a global understanding of how protein sequence determines its phase...…Edited by William A. Eaton, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, and approved February 17, 2021 (received for review September 13, 2020)The tendency of many cellular proteins to form protein-rich biomolecular condensates underlies the formation of subcellular compartments and has been linked to various physiological functions. Understanding the molecular basis of this fundamental process and predicting protein phase behavior have therefore become important objectives. To develop a global understanding of how protein sequence determines its phase...WW…