Edited by Thomas J. Silhavy, Princeton University, Princeton, NJ, and approved February 25, 2021 (received for review September 1, 2020)The outer membrane of gram-negative bacteria is a major deterrent for antibiotic entry, making it difficult to treat these infections. It is composed of both LPS and glycerophospholipids, where the synchronized synthesis between these two components is essential for the outer membrane’s unique permeability barrier. In this report, we identify a previously unidentified association between LPS and glycerophospholipids, where the presence of the complete...…Edited by Thomas J. Silhavy, Princeton University, Princeton, NJ, and approved February 25, 2021 (received for review September 1, 2020)The outer membrane of gram-negative bacteria is a major deterrent for antibiotic entry, making it difficult to treat these infections. It is composed of both LPS and glycerophospholipids, where the synchronized synthesis between these two components is essential for the outer membrane’s unique permeability barrier. In this report, we identify a previously unidentified association between LPS and glycerophospholipids, where the presence of the complete...WW…

Article TextReviewCustomary physical activity and odds of depression: a systematic review and meta-analysis of 111 prospective cohort studiesObjective To explore whether physical activity is inversely associated with the onset of depression, we quantified the cumulative association of customary physical activity with incident depression and with an increase in subclinical depressive symptoms over time as reported from prospective observational studies.Design Systematic review and meta-analysis.Data sources MEDLINE, PsycINFO, PsycARTICLES and CINAHL Complete databases, supplemented by Google...…Article TextReviewCustomary physical activity and odds of depression: a systematic review and meta-analysis of 111 prospective cohort studiesObjective To explore whether physical activity is inversely associated with the onset of depression, we quantified the cumulative association of customary physical activity with incident depression and with an increase in subclinical depressive symptoms over time as reported from prospective observational studies.Design Systematic review and meta-analysis.Data sources MEDLINE, PsycINFO, PsycARTICLES and CINAHL Complete databases, supplemented by Google...WW…