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Donor-derived spermatogenesis following stem cell transplantation in sterile NANOS2 knockout males

Donor-derived spermatogenesis following stem cell transplantation in sterile NANOS2 knockout males

Edited by George E. Seidel, Colorado State University, Fort Collins, CO, and approved July 27, 2020 (received for review May 19, 2020)Transfer of sperm-producing stem cells isolated from a donor male into testes of a recipient male has important applications for preserving germplasm and as a conduit for widespread dissemination of desirable genetics in livestock production. A key aspect is surrogate males that lack endogenous germline but are otherwise physiologically normal. Here we demonstrate that male mice, pigs, and goats rendered genetically sterile by CRISPR-Cas9 editing of the...

September 29, 2020
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