The Salk Institute for Biological Studies
The Salk Institute for Biological Studies
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Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons

Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons

You are currently viewing the abstract.AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.Log in via OpenAthens.Log in with your institution via Shibboleth.Download and print this article for your personal scholarly, research, and educational use.Buy a single issue of Science for just $15 USD.Humans have only a limited capacity to generate new neurons. These cells thus need to repair errors in the genome. To better understand this process, Reid et al. developed Repair-seq, a method...

April 2, 2021
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Microbiota control of maternal behavior regulates early postnatal growth of offspring

Microbiota control of maternal behavior regulates early postnatal growth of offspring

Maternal behavior is necessary for optimal development and growth of offspring. The intestinal microbiota has emerged as a critical regulator of growth and development in the early postnatal period life. Here, we describe the identification of an intestinal Escherichia coli strain that is pathogenic to the maternal-offspring system during the early postnatal stage of life and results in growth stunting of the offspring. However, rather than having a direct pathogenic effect on the infant, we found that this particular E. coli strain was pathogenic to the dams by interfering with the...

January 1, 2021
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