AdvertisementThis article requires a subscription or purchase to view the full text. If you are a subscriber or member, click the login link or the subscribe link in the top menu above to access this article.DOI: Published By: Print ISSN: Online ISSN: History: Copyright & Usage: , , , , , and , , New York, New YorkAddress for correspondence: Dr. Jeffrey I. Mechanick, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1030, New York, New York 10029.The coronavirus disease 2019 (COVID-19) pandemic exposes unexpected cardiovascular...…AdvertisementThis article requires a subscription or purchase to view the full text. If you are a subscriber or member, click the login link or the subscribe link in the top menu above to access this article.DOI: Published By: Print ISSN: Online ISSN: History: Copyright & Usage: , , , , , and , , New York, New YorkAddress for correspondence: Dr. Jeffrey I. Mechanick, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1030, New York, New York 10029.The coronavirus disease 2019 (COVID-19) pandemic exposes unexpected cardiovascular...WW…

› › ›JACC Focus Seminar. , 76 (17) 1999–2010The emergence of a new coronavirus disease (coronavirus disease 2019 [COVID-19]) has raised global concerns regarding the health and safety of a vulnerable population. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) incites a profound inflammatory response leading to tissue injury and organ failure. COVID-19 is characterized by the bidirectional relationship between inflammation and thrombosis. The clinical syndrome is propelled by inflammation producing acute lung injury, large-vessel thrombosis, and in situ...…› › ›JACC Focus Seminar. , 76 (17) 1999–2010The emergence of a new coronavirus disease (coronavirus disease 2019 [COVID-19]) has raised global concerns regarding the health and safety of a vulnerable population. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) incites a profound inflammatory response leading to tissue injury and organ failure. COVID-19 is characterized by the bidirectional relationship between inflammation and thrombosis. The clinical syndrome is propelled by inflammation producing acute lung injury, large-vessel thrombosis, and in situ...WW…

› › ›JACC Focus Seminar. , 76 (17) 2011–2023The cardiovascular system is affected broadly by severe acute respiratory syndrome coronavirus 2 infection. Both direct viral infection and indirect injury resulting from inflammation, endothelial activation, and microvascular thrombosis occur in the context of coronavirus disease 2019. What determines the extent of cardiovascular injury is the amount of viral inoculum, the magnitude of the host immune response, and the presence of co-morbidities. Myocardial injury occurs in approximately one-quarter of hospitalized patients and is...…› › ›JACC Focus Seminar. , 76 (17) 2011–2023The cardiovascular system is affected broadly by severe acute respiratory syndrome coronavirus 2 infection. Both direct viral infection and indirect injury resulting from inflammation, endothelial activation, and microvascular thrombosis occur in the context of coronavirus disease 2019. What determines the extent of cardiovascular injury is the amount of viral inoculum, the magnitude of the host immune response, and the presence of co-morbidities. Myocardial injury occurs in approximately one-quarter of hospitalized patients and is...WW…