Share this articleDoiCopy to clipboardCite this articleMYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1eLife 10:e60191.Copy to clipboardThe oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer therapies. Novel strategies to inhibit MYC may come from understanding the co-factors it uses to drive pro-tumorigenic gene expression programs, providing their role in MYC activity is understood. Here we interrogate how one MYC...…Share this articleDoiCopy to clipboardCite this articleMYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1eLife 10:e60191.Copy to clipboardThe oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer therapies. Novel strategies to inhibit MYC may come from understanding the co-factors it uses to drive pro-tumorigenic gene expression programs, providing their role in MYC activity is understood. Here we interrogate how one MYC...WW…