Share this articleDoiCopy to clipboardCite this articleIsoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorderseLife 9:e56630.Copy to clipboardAKT is implicated in neurological disorders. AKT has three isoforms, AKT1/AKT2/AKT3, with brain cell type-specific expression that may differentially influence behavior. Therefore, we examined single Akt isoform, conditional brain-specific Akt1, and double Akt1/3 mutant mice in behaviors relevant to neuropsychiatric disorders. Because sex is a determinant of these disorders but poorly...…Share this articleDoiCopy to clipboardCite this articleIsoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorderseLife 9:e56630.Copy to clipboardAKT is implicated in neurological disorders. AKT has three isoforms, AKT1/AKT2/AKT3, with brain cell type-specific expression that may differentially influence behavior. Therefore, we examined single Akt isoform, conditional brain-specific Akt1, and double Akt1/3 mutant mice in behaviors relevant to neuropsychiatric disorders. Because sex is a determinant of these disorders but poorly...WW…