Contributed by Jules A. Hoffmann, February 1, 2021 (sent for review January 18, 2021; reviewed by Bruce Beutler and Jeffrey V. Ravetch)Injection of oncogenic RasV12 cells into male flies induces the up-regulation of several hundreds of genes, many of which code for chemoreceptors, but not for proteins involved in the classical fly defenses against foreign invaders (e.g., microbes). Injection further induces stress-related and inflammatory-like responses within the flies. Over time, the injected cells change their transcriptomic profiles within the host, and a majority evolve into classical...…Contributed by Jules A. Hoffmann, February 1, 2021 (sent for review January 18, 2021; reviewed by Bruce Beutler and Jeffrey V. Ravetch)Injection of oncogenic RasV12 cells into male flies induces the up-regulation of several hundreds of genes, many of which code for chemoreceptors, but not for proteins involved in the classical fly defenses against foreign invaders (e.g., microbes). Injection further induces stress-related and inflammatory-like responses within the flies. Over time, the injected cells change their transcriptomic profiles within the host, and a majority evolve into classical...WW…