Edited by Alice Telesnitsky, University of Michigan Medical School, Ann Arbor, MI, and accepted by Editorial Board Member Michael F. Summers February 25, 2021 (received for review October 28, 2020)Studies on bacterial and eukaryotic viruses have revealed a range of strategies used by viruses to subdue host cells for efficient virus replication. How archaeal viruses interact with their hosts remains largely unknown. We characterize a new strategy employed by a nonlytic archaeal virus STSV2 to transform its host into a giant virion-producing factory, whereby the virus infection blocks normal...…Edited by Alice Telesnitsky, University of Michigan Medical School, Ann Arbor, MI, and accepted by Editorial Board Member Michael F. Summers February 25, 2021 (received for review October 28, 2020)Studies on bacterial and eukaryotic viruses have revealed a range of strategies used by viruses to subdue host cells for efficient virus replication. How archaeal viruses interact with their hosts remains largely unknown. We characterize a new strategy employed by a nonlytic archaeal virus STSV2 to transform its host into a giant virion-producing factory, whereby the virus infection blocks normal...WW…