Edited by Elsa M. Redmond, American Museum of Natural History, New York, NY, and approved February 17, 2021 (received for review December 14, 2020)Different models have been proposed to elucidate the origins of the founding populations of America, along with the number of migratory waves and routes used by these first explorers. Settlements, both along the Pacific coast and on land, have been evidenced in genetic and archeological studies. However, the number of migratory waves and the origin of immigrants are still controversial topics. Here, we show the Australasian genetic signal is...…Edited by Elsa M. Redmond, American Museum of Natural History, New York, NY, and approved February 17, 2021 (received for review December 14, 2020)Different models have been proposed to elucidate the origins of the founding populations of America, along with the number of migratory waves and routes used by these first explorers. Settlements, both along the Pacific coast and on land, have been evidenced in genetic and archeological studies. However, the number of migratory waves and the origin of immigrants are still controversial topics. Here, we show the Australasian genetic signal is...WW…