Name: Maternal obesity and long-term neuropsychiatric morbidity of the offspring - Archives of Gynecology and Obstetrics
Brand: springer.com
SKU: springer-com-4
Availability: OnlineOnly

critic

Maternal obesity and long-term neuropsychiatric morbidity of the offspring - Archives of Gynecology and Obstetrics

preview

AdvertisementTo evaluate the long-term pediatric neuropsychiatric morbidity of children born to obese patients.A population-based cohort analysis was performed comparing all deliveries of obese (maternal pre-pregnancy body mass index of 30&nbsp;kg/m2 or more) and non-obese patients between 1991 and 2014 at a single tertiary medical center. Hospitalizations of the offspring up to the age of 18&nbsp;years involving neuropsychiatric morbidities were evaluated according to a pre-defined set of ICD-9 codes, including autistic, eating, sleeping and movement disorders, cerebral palsy, developmental disorders, and more. A Kaplan–Meier survival curve was used to compare cumulative hospitalization rate in exposed and unexposed offspring. A Cox regression model was used to control for confounders.During the study period, 242,342 deliveries met the inclusion criteria. Of them, 3290 were children of obese mothers. Hospitalizations involving neuropsychiatric morbidities were higher in children born to obese mothers compared with those born to non-obese mothers (3.95% vs. 3.10%, p &lt; 0.01). Specifically, offspring of obese mothers had higher rates of autism spectrum disorders and psychiatric disorders. The Kaplan–Meier survival curve demonstrated a significantly higher cumulative incidence of neuropsychiatric-related hospitalizations in the obese group (Fig.&nbsp;1, log rank p &lt; 0.05). Using a cox proportional hazard model, controlling for maternal age, preterm labor, maternal diabetes, hypertensive disorders of pregnancy, and birthweight, maternal obesity was found to be independently associated with long-term neuropsychiatric morbidity of the offspring (adjusted HR 1.24, 95% CI 1.04–1.47, p &lt; 0.05).Maternal obesity is an independent risk factor for long-term neuropsychiatric morbidity of the offspring.This is a preview of subscription content, .Instant access to the full article PDF.USD 39.95Price excludes VAT (USA)Tax calculation will be finalised during checkout.Willis K, Lieberman N, Sheiner E (2015) Pregnancy and neonatal outcome after bariatric surgery. Best Pract Res Clin Obstet Gynaecol 29(1):133–144&nbsp;&nbsp;Mission JF, Marshall NE, Caughey AB (2015) Pregnancy risks associated with obesity. Obstet Gynecol Clin North Am 42(2):335–353&nbsp;&nbsp;Burstein E, Levy A, Mazor M, Wiznitzer A, Sheiner E (2008) Pregnancy outcome among obese women: a prospective study. Am J Perinatol 25(9):561–566&nbsp;&nbsp;Sheiner E, Levy A, Menes TS, Silverberg D, Katz M, Mazor M (2004) Maternal obesity as an independent risk factor for caesarean delivery. Paediatr Perinat Epidemiol 18(3):196–201&nbsp;&nbsp;Gilead R, Yaniv Salem S, Sergienko R, Sheiner E (2012) Maternal, “isolated” obesity and obstetric complications. J Matern Fetal Neonatal Med 25(12):2579–2582&nbsp;&nbsp;Yaniv-Salem S, Shoham-Vardi I, Kessous R, Pariente G, Sergienko R, Sheiner E (2016) Obesity in pregnancy: what’s next? Long-term cardiovascular morbidity in a follow-up period of more than a decade. J Matern Fetal Neonatal Med 29(4):619–623&nbsp;&nbsp;&nbsp;Sasson I, Beharier O, Sergienko R, Szaingurten-Solodkin I, Kessous R, Belfair NJ et al (2016) Obesity during pregnancy and long-term risk for ophthalmic morbidity—a population-based study with a follow-up of more than a decade. J Matern Fetal Neonatal Med 29(18):2924–2928&nbsp;&nbsp;Kessous R, Davidson E, Meirovitz M, Sergienko R, Sheiner E (2017) Prepregnancy obesity: a risk factor for future development of ovarian and breast cancer. Eur J Cancer Prev 26(2):151–155&nbsp;&nbsp;Marchi J, Berg M, Dencker A, Olander E, Begley C (2015) Risks associated with obesity in pregnancy, for the mother and baby: a systematic review of reviews. Obes Rev 16(8):621–638&nbsp;&nbsp;&nbsp;Ovesen P, Rasmussen S, Kesmodel U (2011) Effect of prepregnancy maternal overweight and obesity on pregnancy outcome. Obstet Gynecol 118(2 Pt 1):305–312&nbsp;&nbsp;Kleitman V, Feldman R, Walfisch A, Toledano R, Sheiner E (2016) Recurrent shoulder dystocia: is it predictable? Arch Gynecol Obstet 294(6):1161–1166&nbsp;&nbsp;Okby R, Sheiner E (2012) Risk factors for neonatal brachial plexus paralysis. Arch Gynecol Obstet 286(2):333–336&nbsp;&nbsp;Doherty DA, Magann EF, Francis J, Morrison JC, Newnham JP (2006) Pre-pregnancy body mass index and pregnancy outcomes. Int J Gynaecol Obstet 95(3):242–247&nbsp;&nbsp;&nbsp;Mitanchez D, Chavatte-Palmer P (2018) Review shows that maternal obesity induces serious adverse neonatal effects and is associated with childhood obesity in their offspring. Acta Paediatr 107(7):1156–1165&nbsp;&nbsp;Galliano D, Bellver J (2013) Female obesity: short- and long-term consequences on the offspring. Gynecol Endocrinol 29(7):626–631&nbsp;&nbsp;Contu L, Hawkes C (2017) A review of the impact of maternal obesity on the cognitive function and mental health of the offspring. Int J Mol Sci 18(5):1093&nbsp;&nbsp;Edlow AG (2017) Maternal obesity and neurodevelopmental and psychiatric disorders in offspring. Prenat Diagn 37(1):95&nbsp;&nbsp;Sanchez CE, Barry C, Sabhlok A, Russell K, Majors A, Kollins SH et al (2018) Maternal pre-pregnancy obesity and child neurodevelopmental outcomes: a meta-analysis. Obes Rev 19(4):464&nbsp;&nbsp;&nbsp;Wang Y, Tang S, Xu S, Weng S, Liu Z (2016) Maternal body mass index and risk of autism spectrum disorders in offspring: a meta-analysis. Sci Rep 6:34248&nbsp;&nbsp;&nbsp;Krakowiak P, Walker CK, Bremer AA, Baker AS, Ozonoff S, Hansen RL et al (2012) Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. Pediatrics 129(5):e1121&nbsp;&nbsp;Getz KD, Anderka MT, Werler MM, Jick SS (2016) Maternal pre-pregnancy body mass index and autism spectrum disorder among offspring: a population-based case–control study. Paediatr Perinat Epidemiol 30(5):479–487&nbsp;&nbsp;Andersen CH, Thomsen PH, Nohr EA, Lemcke S (2018) Maternal body mass index before pregnancy as a risk factor for ADHD and autism in children. Eur Child Adolesc Psychiatry 27(2):139–148&nbsp;&nbsp;Khandaker GM, Dibben CRM, Jones PB (2012) Does maternal body mass index during pregnancy influence risk of schizophrenia in the adult offspring? Obes Rev 13(6):518&nbsp;&nbsp;&nbsp;Kong LH, Norstedt G, Schalling M, Gissler M, Lavebratt C (2018) The risk of offspring psychiatric disorders in the setting of maternal obesity and diabetes. Pediatrics.&nbsp;&nbsp;&nbsp;&nbsp;Schaefer CA, Brown AS, Wyatt RJ, Kline J, Begg MD, Bresnahan MA et al (2000) Maternal prepregnant body mass and risk of schizophrenia in adult offspring. Schizophr Bull 26(2):275–286&nbsp;&nbsp;&nbsp;Robinson M, Zubrick SR, Pennell CE, Van Lieshout RJ, Jacoby P, Beilin LJ et al (2013) Pre-pregnancy maternal overweight and obesity increase the risk for affective disorders in offspring. J Dev Orig Health Dis 4(1):42–48&nbsp;&nbsp;&nbsp;Sullivan EL, Riper KM, Lockard R, Valleau JC (2015) Maternal high-fat diet programming of the neuroendocrine system and behavior. Horm Behav 76:153–161&nbsp;&nbsp;&nbsp;Perng W, Gillman MW, Mantzoros CS, Oken E (2014) A prospective study of maternal prenatal weight and offspring cardiometabolic health in midchildhood. Ann Epidemiol 24(11):800.e1&nbsp;&nbsp;Ashwood P, Kwong C, Hansen R, Hertz-Picciotto I, Croen L, Krakowiak P et al (2008) Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype? J Autism Dev Disord 38(1):169–175&nbsp;&nbsp;van der Burg JW, Sen S, Chomitz V, Seidell J, Leviton A, Dammann O (2016) The role of systemic inflammation linking maternal BMI to neurodevelopment in children. Pediatr Res 79(1):3–12&nbsp;&nbsp;Li YM, Ou JJ, Liu L, Zhang D, Zhao JP, Tang SY (2016) Association between maternal obesity and autism spectrum disorder in offspring: a meta-analysis. J Autism Dev Disord 46(1):95–102&nbsp;&nbsp;Connolly N, Anixt J, Manning P, Ping-I Lin D, Marsolo KA, Bowers K (2016) Maternal metabolic risk factors for autism spectrum disorder—an analysis of electronic medical records and linked birth data. Autism Res 9(8):829&nbsp;&nbsp;Maher G, O’Keeffe G, Kearney P, Kenny LC, Dinan T, Mattsson M et al (2018) Association of hypertensive disorders of pregnancy with risk of neurodevelopmental disorders in offspring a systematic review and meta-analysis. JAMA Psychiatry 75(8):809–819&nbsp;&nbsp;Sheiner E, Shoham-Vardi I, Weitzman D, Gohar J, Carmi R (1998) Decisions regarding pregnancy termination among Bedouin couples referred to third level ultrasound clinic. Eur J Obstet Gynecol Reprod Biol 76(2):141–146&nbsp;&nbsp;&nbsp;Abu-Ghanem S, Sheiner E, Sherf M, Wiznitzer A, Sergienko R, Shoham-Vardi I (2012) Lack of prenatal care in a traditional community: trends and perinatal outcomes. Arch Gynecol Obstet 285(5):1237–1242&nbsp;&nbsp;This study was conducted as part of the requirements for graduation from the Medical School of the Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel.This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.The authors declare that they have no conflict of interests.This is a retrospective study. No informed consent was needed.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Below is the link to the electronic supplementary material.Neuhaus, Z.F., Gutvirtz, G., Pariente, G. et al. Maternal obesity and long-term neuropsychiatric morbidity of the offspring.Arch Gynecol Obstet 301, 143–149 (2020). https://doi.org/10.1007/s00404-020-05432-6Anyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboardProvided by the Springer Nature SharedIt content-sharing initiativeInstant access to the full article PDF.USD 39.95Price excludes VAT (USA)Tax calculation will be finalised during checkout.Advertisement

AdvertisementTo evaluate the long-term pediatric neuropsychiatric morbidity of children born to obese patients.A population-based cohort analysis was performed comparing all deliveries of obese (maternal pre-pregnancy body mass index of 30&nbsp;kg/m2 or more) and non-obese patients between 1991 and 2014 at a single tertiary medical center. Hospitalizations of the offspring up to the age of 18&nbsp;years involving neuropsychiatric morbidities were evaluated according to a pre-defined set of ICD-9 codes, including autistic, eating, sleeping and movement disorders, cerebral palsy,...

Maternal obesity and long-term neuropsychiatric morbidity of the offspring - Archives of Gynecology and Obstetrics

No article scores yet.

CRITIC REVIEWS

PUBLIC REVIEWS