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Cincinnati researchers working to understand most threatening COVID-19 variant

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AdvertisementCincinnati researchers working to understand most threatening COVID-19 variantHide TranscriptShow TranscriptVACCINE, BUT THIS ONE HAS BEEN TWEAKED LIKE IN APPROACHING STORM THE SOUTH AFRICAN VARIANT HAS EMERGED AS SOMETHING TO WATCH ON THE RESEARCH RADAR. IT’S HARDER TO NEUTRALIZE. IT’S IT’S STILL CAN BE NEUTRALIZED BUT IT’S IT’S A CONCERN FOR THE FUTURE IF IT CONTINUES TO SPREAD DR. PAUL SPEARMAN IS DIRECTOR OF INFECTIOUS DISEASE AND CINCINNATI. HIS HOSPITAL HE’S HEADING UP RESEARCH ON A TWEAKED VERSION OF THE MODERNA VACCINE ONE OF THE ADVANTAGES OF THE MRNA VACCINES, YOU KNOW IS THAT THEY CAN BE MODIFIED RELATIVELY QUICKLY. AND SO THAT’S WHY THIS TRIAL IS ACTUALLY HAPPENING VERY QUICKLY AFTER THE PREVIOUS VACCINE WAS AUTHORIZED. WHO WOULD CLOUDS ARE YET DEPORT WHILE THERE IS NO EVIDENCE THAT THE SOUTH AFRICAN VARIANT HAS MUTATED SO MUCH. IT CAN COMPLETELY EVADE CURRENT VACCINES. EARLY ANALYSIS SHOWS SOME ARE LESS EFFECTIVE AGAINST IT CONCERNING ENOUGH THAT RESEARCH IS ALREADY BEGINNING. WE DON’T KNOW THAT WE ACTUALLY NEED TO MODIFY THAT VACCINE IN ORDER TO HAVE EFFECTIVENESS AGAINST THE SOUTH AFRICAN STRAIN, BUT IN CASE WE DO THIS TRIAL IS GOING TO REALLY EVALUATE THAT CINCINNATI CHILDREN’S HOSPITAL WILL BE ONLY ONE OF FORESIGHTS IN THE US TESTING THE NEW MODERN VACCINE RESEARCHERS CAN EVALUATE THE RESPONSE TO THE NEW VACCINE FORMULA. MATTER OF MONTHS SO AS THINGS CHANGE WE MAY NOT NEED TO START OVER BUT WE MAY BE ABLE TO GIVE A BOOSTER AND WE WANT TO KNOW WHAT TYPE OF BOOSTERS GOING TO WORK REALLY WELL AS SCIENTISTS LOOK AHEAD TO GET IN FRONT OF THE MUTATIONS AS THEY FORECAST THE FUTURE THE VIRUS. YEAH, THEY’LL NEED 30 TO 50 VOLUNTEERS AT CHILDREN’S HOSPITAL AND ONLY ABOUT 210 ACROSS THE COUNTRY TO DETERMINE IF THIS TWEAKED VERSION OF THE MODERNA VACCINE WORKS AGAINST THIS SOUTH AFRICAN VARIANT.AdvertisementCincinnati researchers working to understand most threatening COVID-19 variantResearchers in Cincinnati are beginning trials in the effort to battle the most concerning COVID-19 variant now emerging.“There are a lot of variants out there. One of the ones people are most concerned about is the South African variant,” said Dr. Paul Spearman.Spearman is director of infectious disease at Cincinnati Children’s Hospital.“It’s harder to neutralize. It still can be neutralized, but it’s a concern for the future if it continues to spread,” Spearman said.Spearman is heading up the research on a “tweaked” version of the Moderna vaccine that will target the South African variant.“This one is formally known as b.1.351 or we just call it 351. The reason people are concerned about that is it looks like some of the vaccines that were being evaluated in South Africa at the time this virus was spreading, they were less effective in that population,” Spearman said.Children’s Hospital will test between 30 and 50 people. The trial will measure immune response.“One of the advantages of the mRNA vaccines is that they can be modified relatively quickly. That’s why this trial is being offered so quickly after this vaccine was authorized,” Spearman said.Researchers in Cincinnati are beginning trials in the effort to battle the most concerning COVID-19 variant now emerging.“There are a lot of variants out there. One of the ones people are most concerned about is the South African variant,” said Dr. Paul Spearman.AdvertisementSpearman is director of infectious disease at Cincinnati Children’s Hospital.“It’s harder to neutralize. It still can be neutralized, but it’s a concern for the future if it continues to spread,” Spearman said.Spearman is heading up the research on a “tweaked” version of the Moderna vaccine that will target the South African variant.“This one is formally known as b.1.351 or we just call it 351. The reason people are concerned about that is it looks like some of the vaccines that were being evaluated in South Africa at the time this virus was spreading, they were less effective in that population,” Spearman said.Children’s Hospital will test between 30 and 50 people. The trial will measure immune response.“One of the advantages of the mRNA vaccines is that they can be modified relatively quickly. That’s why this trial is being offered so quickly after this vaccine was authorized,” Spearman said.Loading more articles...

AdvertisementCincinnati researchers working to understand most threatening COVID-19 variantHide TranscriptShow TranscriptVACCINE, BUT THIS ONE HAS BEEN TWEAKED LIKE IN APPROACHING STORM THE SOUTH AFRICAN VARIANT HAS EMERGED AS SOMETHING TO WATCH ON THE RESEARCH RADAR. IT’S HARDER TO NEUTRALIZE. IT’S IT’S STILL CAN BE NEUTRALIZED BUT IT’S IT’S A CONCERN FOR THE FUTURE IF IT CONTINUES TO SPREAD DR. PAUL SPEARMAN IS DIRECTOR OF INFECTIOUS DISEASE AND CINCINNATI. HIS HOSPITAL HE’S HEADING UP RESEARCH ON A TWEAKED VERSION OF THE MODERNA VACCINE ONE OF THE ADVANTAGES OF THE MRNA VACCINES, YOU...

Cincinnati researchers working to understand most threatening COVID-19 variant

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