Name: 'Dumbest senator ever': Morning Joe mocks Republican Ron Johnson
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'Dumbest senator ever': Morning Joe mocks Republican Ron Johnson

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--Report typos and corrections to: .Mental illness is a growing public health problem. In 2019, an estimated were affected by mental disorders like depression, schizophrenia or bipolar disorder. While scientists have long known that many of these disorders run in families, their genetic basis isn’t entirely clear. One reason why is that the majority of existing genetic data used in research is overwhelmingly from white people.In 2003, the Human Genome Project generated the first “reference genome” of human DNA from a combination of samples donated by , all of whom were of European ancestry. Researchers across many biomedical fields still use this reference genome in their work. But it doesn’t provide a complete picture of human genetics. Someone with a different genetic ancestry will have a number of in their DNA that aren’t captured by the reference sequence.When most of the world’s ancestries are not represented in genomic data sets, studies won’t be able to provide a true representation of how diseases manifest across all of humanity. Despite this, ancestral diversity in genetic analyses hasn’t improved in the two decades since the Human Genome Project announced its first results. As of June 2021, of genetic studies have been conducted on people of European descent. Less than 2% have included people of African descent, even though these individuals have the of all human populations.To uncover the driving mental illness, , and our colleagues at the Broad Institute of MIT and Harvard have partnered with collaborators around the world to launch , an initiative that seeks to collect a more diverse range of genetic samples from beyond the U.S. and Northern Europe, and train the around the world. Not only does the genetic data lack diversity, but so do the tools and techniques scientists use to sequence and analyze human genomes. So we are implementing a new sequencing technology that addresses the inadequacies of previous approaches that don’t account for the genetic diversity of global populations. Ethically and equitably expanding the diversity of genomics data can help improve care and reduce disparities.To study the genetics of psychiatric conditions, researchers use data from that compare the genetic variations between people with and without a particular disease. However, these data sets are mostly , largely because research infrastructure and funding for large-scale genetics studies, and the scientists conducting these studies, have historically been concentrated in Europe and the United States.One way to close this gap is to sequence genetic data from diverse populations. My colleagues and I are working in close partnership with geneticists, statisticians and epidemiologists in 14 countries across four continents to study the DNA of tens of thousands of people of African, Asian and Latino ancestries who are affected by mental illness. We work together to recruit participants and collect DNA samples that are sequenced at the Broad Institute in Massachusetts and shared with all partners for analysis. of local communities and scientists is foundational to our work. All partners have joint ownership of the project, including decision-making and sample and data ownership and control. To do this, we build relationships and trust with the local communities we are studying and the local university leaders and scientists with whom we are partnering. We work to understand local cultures and practices, and adapt our collection methods to ensure study participants are comfortable. For example, because there are different cultural sensitivities around providing saliva and blood samples, we have adapted our practices by location to ensure study participants are comfortable.We also freely share knowledge and materials with our partners. There is a two-way exchange of information between the Broad Institute and local teams on study progress and results, enabling continual learning, teaching and unity between teams. We strive to meet each other where we are by exchanging practices and training scientists to support the development of locally grown and locally led research programs. The Global Initiative for Neuropsychiatric Genetics Education in Research (GINGER) program is focused on training the next generation of scientists. , Our collaboration with African research groups provides a prime example of . For example, our African research colleagues are co-leaders on the grants that fund the lab equipment, scientists and other staff for projects based at their study sites. And we help to support the next generation of African geneticists and bioinformaticians through a .Collecting samples from more diverse populations is only half of the challenge. Existing genomic sequencing and analysis technologies do not adequately capture genetic variation across populations from around the world. That’s because these technologies were designed to detect genetic variations based on reference DNA from people of European ancestry, and they when analyzing sequences that aren’t derived from the reference genome. When these tools are applied to genetic data from other populations, they in their genomes. This can lead researchers to miss out on important biomedical discoveries. To address this issue, we developed an approach to genome sequencing that can detect more genetic variation from populations around the world. It works by sequencing the – the less than 2% of the genome that codes for proteins – in high detail, as well as sequencing the 98% of the genome that does not code for proteins in less detail. Different types of sequencing methods have pros and cons.This combined approach reduces the trade-offs geneticists often have to make in sequencing projects. , which reads through the entire genome multiple times to get detailed data, is too costly to do on a large number of DNA samples. While reduces costs by reading smaller segments of the genome, it may miss some important genetic variation. With our new technology, geneticists can get the best of both worlds: maximizes the likelihood of pinpointing that play a role in mental illness, while allows researchers to process large numbers of whole genomes more cost-effectively.Our hope is that this new technology will allow researchers to sequence large sample sizes from a diverse range of ancestries to capture the full breadth of genetic variation. With a better understanding of the genetics of mental illness, clinicians and researchers will be better equipped to develop new treatments that work for everyone. Genomic sequencing opened a new era of , which promises to deliver treatments tailored to each individual person. This can be done only if the genetic variations of all ancestries are represented in the data sets that researchers use to make new discoveries about disease and develop treatments., Assistant Professor of Medicine, This article is republished from under a Creative Commons license. Read the .is a series for children of all ages. If you have a question you’d like an expert to answer, send it to .How do ants crawl on walls? – Ethan, age 9, Dallas, TexasFacing mounting opposition from environmentalists, frontline communities, and fellow Democratic lawmakers, Sen. Joe Manchin is reportedly asking oil and gas executives to help him build Republican support for permitting legislation that aims to weaken bedrock environmental laws and ease the review process for dirty energy projects.Bloomberg Monday that Manchin's outreach "has included companies in the mining, utilities, and oil and gas industry," all of which stand to benefit from a federal permitting overhaul—and all of which to the West Virginia Democrat's political campaigns."Give us a clean CR and let these dirty permitting provisions stand up to congressional scrutiny on their own.""Passing the legislation would mark a big win for the industry and its long-sought efforts to accelerate permitting and scale back environmental reviews that can take years," Bloomberg noted. "Among projects that could benefit is a stalled $6.6 billion Mountain Valley natural gas pipeline—which would help to unlock more supplies of the fuel from the Marcellus shale.""Manchin is set to address chief executive officers at the Washington-based Business Roundtable's quarterly meeting later this week," the outlet added, citing a person familiar with the senator's plans.While changes to federal permitting laws clean energy projects, environmentalists and the of members of the Democratic caucus say the acceleration of pipeline approvals and other fossil fuel infrastructure would undermine U.S. climate goals and harm local communities, negating the potential benefits."A leaked of a side deal to weaken and truncate environmental reviews is nothing more than the wishlist for all extractive industries," reads a that more than 160 advocacy groups sent to Democratic leaders Monday. "There is no way to mitigate the damage that would be done by this side deal, it must be unequivocally rejected."As part of a deal to secure Manchin's support for the recently passed Inflation Reduction Act, Democratic leaders agreed to hold a vote on permitting reforms that the senator and his industry allies have long demanded.Senate Majority Leader Chuck Schumer (D-N.Y.) and House Speaker Nancy Pelosi (D-Calif.) are expected to attach a permitting reform bill to a government funding measure that must pass by the end of the month to avoid a shutdown. The White House said Monday that President Joe Biden is to advancing permitting reforms.Depending on how many Senate Democrats oppose the permitting deal, Manchin may need to win more than 10 Republican votes. Thus far, Sen. Bernie Sanders (I-Vt.) is the of the Senate Democratic caucus to vow to vote against a government funding package that includes permitting reforms.As Manchin enlists fossil fuel executives to get the GOP on board with his yet-to-be-released bill amid growing pushback from members of his own party, dozens of Republicans led by Sen. Shelley Moore Capito (R-W.Va.) are pursuing that climate groups warn would be even more damaging to the environment.According to a summary released by Capito's office Monday, the GOP bill would codify former President Donald Trump's on the National Environmental Policy Act (NEPA) and the and bar the adoption of the Biden administration's "social cost of greenhouse gases" ."This so-called 'permitting reform' bill is nothing more than a shameless attempt to make it easier for fossil fuel companies to steamroll communities and fast-track their polluting projects," said Mahyar Sorour, Sierra Club's deputy legislative director. "Efforts to weaken NEPA and limit the public's ability to weigh in on pipelines and other infrastructure that would affect them would be devastating for our communities, especially in places like Appalachia and the Gulf South that have already been treated as fossil fuel sacrifice zones for far too long."While Manchin didn't explicitly endorse Capito's bill, he Monday that it is "wonderful that we're all on the same page—we all know that we need to have permitting reform."Many of Manchin's Democratic colleagues disagree. On Friday, 72 House Democrats released a letter to the proposed federal permitting overhaul and denounced plans to attach it to must-pass government funding legislation.Since Friday, five additional House Democrats have ."I don't know how a [continuing resolution] vote will go if it includes the permitting rider, but the opposition is loud and only getting louder," Rep. Raúl Grijalva (D-Ariz.), the letter's chief organizer, said Monday."I encourage leadership to listen to its caucus and keep us out of a shutdown standoff that nobody wants," he added. "Give us a clean CR and let these dirty permitting provisions stand up to congressional scrutiny on their own. Now is not the time to roll the dice on a government shutdown."&nbsp;&nbsp;&nbsp;Copyright © 2022 Raw Story Media, Inc. PO Box 21050, Washington, D.C. 20009 | | | For corrections or concerns, please email corrections@rawstory.com. | {{ post.roar_specific_data.api_data.analytics }}

--Report typos and corrections to: .Mental illness is a growing public health problem. In 2019, an estimated were affected by mental disorders like depression, schizophrenia or bipolar disorder. While scientists have long known that many of these disorders run in families, their genetic basis isn’t entirely clear. One reason why is that the majority of existing genetic data used in research is overwhelmingly from white people.In 2003, the Human Genome Project generated the first “reference genome” of human DNA from a combination of samples donated by , all of whom were of European ancestry....

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The Raw Story (also stylized as RawStory) is an American online tabloid founded in 2004 by John K. Byrne. It covers current national and international political events and publishes its own editorials which tend to advocate for progressive positions. The Raw Story is a news site, bringing attention to stories that it sees as downplayed or ignored by other media outlets.

'Dumbest senator ever': Morning Joe mocks Republican Ron Johnson

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