Name: Organic compounds called phenazines can kill cancer cells while leaving others unharmed, suggest scientists-India News , Firstpost
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Organic compounds called phenazines can kill cancer cells while leaving others unharmed, suggest scientists-India News , Firstpost

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SectionsMoreShowsrn rnF.BrandsScientists at the Tokyo University of Science are now hoping to take the findings of their study further by conducting animal studies and clinical trials to see if phenazinones, a category of phenazines, can be developed into anticancer drugsRepresentational image. Unsplash@National Cancer InstituteOne in five men and one in six women worldwide develop cancer during their lifetime. One in eight men and one in 11 women die from cancer. In 2018, the World Health Organization (WHO) revealed this estimate while also pointing out that there were 18.1 million new cases of cancer and 9.6 million deaths due to the disease in that year alone.The current five-year prevalence (the total number of people who are alive within five years of a cancer diagnosis) is estimated to be 43.8 million.These staggering statistics indicate that the global cancer burden is rising. Cancer research from around the world has been focused on tackling this disease and providing appropriate therapies and drugs for decades now. A new study published in the American Chemical Society Omega offers the hope of a cancer cure. It suggests a set of organic compounds called phenazines could be effective in targeting and killing cancer cells in the body while leaving healthy cells unharmed.Phenazines and cytotoxicityCytotoxicity is an exciting concept in cancer research that refers to the ability to kill cancer cells. Researchers have been devising experimental cytotoxic drugs and chemotherapy that inhibit cell division, starves the cells, and thereby cause them to die. However, the problem with cytotoxics is that they can kill healthy cells while targeting cancer cells in the body, which leads to a different set of health issues altogether.To counter this potential harm that can be caused by cytotoxic drugs, the researchers behind this new study — who are all based out of the Tokyo University of Science — turned towards phenazines. Phenazines are a large group of organic compounds that contain nitrogen and have a ring structure with at least two different elements. Though a large number of phenazines are naturally found in certain bacteria, they can be difficult to synthesise to create drugs. The scientists focused on one type of these phenazines, a category known as phenazinones (N-alkyl-2-halophenazin-1-ones), which reportedly has antibacterial, antifungal, and cytotoxic properties.Synthesising phenazines to kill cancer cellsThe researchers managed to synthesise a number of phenazinones like WS-9659 B, 2-chloropyocyanin and marinocyanins A and B. The cytotoxicity of these synthesised phenazines was then tested against human promyelocytic leukemia HL-60 cells, human lung cancer A549 cells and normal or healthy MRC-5 cells. Of all the compounds tested, the researchers found that 2-chloropyocyanin was able to selectively target the lung cancer A549 cells while leaving the healthy cells completely unharmed.This cytotoxicity evaluation suggests that there is at least one type of phenazine which can be synthesised into potential drugs that can target cancer cells while leaving healthy cells unaffected. The scientists also found that these phenanizones are at least four times more selectively toxic against cancer cells than other cytotoxic compounds.They now hope to take the findings of their study further by conducting animal studies and clinical trials to see if phenazinones can be developed into anticancer drugs that can be widely used to reduce the heavy burden of this disease.For more information, read our article on .&nbsp;Health articles in Firstpost are written by myUpchar.com, India’s first and biggest resource for verified medical information. At myUpchar, researchers and journalists work with doctors to bring you information on all things health.TAGS:The information provided here is intended to provide free education about certain medical conditions and certain possible treatment. It is not a substitute for examination, diagnosis, treatment, and medical care provided by a licensed and qualified health professional. If you believe you, your child or someone you know suffers from the conditions described herein, please see your health care provider immediately. Do not attempt to treat yourself, your child, or anyone else without proper medical supervision. You acknowledge and agree that neither myUpchar nor firstpost is liable for any loss or damage which may be incurred by you as a result of the information provided here, or as a result of any reliance placed by you on the completeness, accuracy or existence of any information provided herein.Smokers are at risk of dying earlier due to stroke, heart disease and cancersThe premier higher education and research institute has entered into a MoU with Karkinos Healthcare Private Limited. A Centre of Advanced Research on Diagnostics in Cancer (C-CARD), the first of its kind in the country with an IIT, will be set up at the premises of the instituteThe Serum Institute of India and the Department of Biotechnology are set to launch India's first indigenously developed Quadrivalent Human Papillomavirus vaccine (qHPV) against cervical cancer on 1 September, official sources said.

SectionsMoreShowsrn rnF.BrandsScientists at the Tokyo University of Science are now hoping to take the findings of their study further by conducting animal studies and clinical trials to see if phenazinones, a category of phenazines, can be developed into anticancer drugsRepresentational image. Unsplash@National Cancer InstituteOne in five men and one in six women worldwide develop cancer during their lifetime. One in eight men and one in 11 women die from cancer. In 2018, the World Health Organization (WHO) revealed this estimate while also pointing out that there were 18.1 million new...

Organic compounds called phenazines can kill cancer cells while leaving others unharmed, suggest scientists-India News , Firstpost

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