Name: UBC professor uses knowledge of SARS to develop COVID-19 drug | Globalnews.ca
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UBC professor uses knowledge of SARS to develop COVID-19 drug | Globalnews.ca

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Want to discuss? Please read our first.AdvertisementClose XAAA B.C. doctor who helped discover an enzyme and develop a drug to stop the spread of SARS more than 20 years ago is using that knowledge to fight .Dr. Josef Penninger, a UBC life sciences institute director, co-discovered an enzyme called ACE2 while working as a researcher in Toronto in the late ’90s.A few years later, during the SARS epidemic, Penninger discovered that ACE2 was the virus’ gateway into healthy cells, where they both replicated and destroyed tissue. In the case of SARS, it was lung tissue in particular.He then developed a drug that blocked the enzyme and stopped the virus from entering healthy tissue.Soon after, the number of SARS cases began to drop around the world — along with funding for clinical trials. Story continues below advertisementWhen COVID-19, which is also a coronavirus like SARS, began to spread, Penninger resurrected his research.[ ]Due to his previous work during the SARS outbreak, he was able to begin clinical trials well before other researchers.On Thursday, the promising findings of the first clinical trial of his new treatment were released in the Lancet Medical Journal.The patient, a 45-year-old woman in Vienna who was on a ventilator due to severe COVID-19 symptoms, showed improvement shortly after receiving the drug known as APN01.“In one or two days, the virus disappeared in her blood system and also in her lungs,” Penninger told Global News. “Secondly, the cytokine storm went down within two to three days. She developed perfect immunity from the virus.” Story continues below advertisement“She is now back home and healthy.”A cytokine storm is an overreaction of the body’s immune system, which can be fatal if someone has COVID-19.Study recruitment is still underway around the world, with the hope that the results from 200 other severe cases of COVID-19 patients will be published by November.If all goes well, Penninger said there could be a drug ready for market by early next year.© 2020 Global News, a division of Corus Entertainment Inc.CommentsAdvertisementStay in the loopGet a roundup of the most important and intriguing stories, delivered to your inboxSign up for Health IQ newsletterSign UpStay in the loopGet a roundup of the most important and intriguing stories, delivered to your inboxSign up for Health IQ newsletterSign UpAdvertisement

Want to discuss? Please read our first.AdvertisementClose XAAA B.C. doctor who helped discover an enzyme and develop a drug to stop the spread of SARS more than 20 years ago is using that knowledge to fight .Dr. Josef Penninger, a UBC life sciences institute director, co-discovered an enzyme called ACE2 while working as a researcher in Toronto in the late ’90s.A few years later, during the SARS epidemic, Penninger discovered that ACE2 was the virus’ gateway into healthy cells, where they both replicated and destroyed tissue. In the case of SARS, it was lung tissue in particular.He then...

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Linda Aylesworth

Global News is the news and current affairs division of the Global Television Network. The network is owned by Corus Entertainment, which oversees all of the network's national news programming as well as local news on its 15 owned-and-operated stations.  Corus also operates several talk radio stations under the "Global News Radio" brand. The same division also operates a news website under the same brand.

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UBC professor uses knowledge of SARS to develop COVID-19 drug | Globalnews.ca

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